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A small molecule that disrupts S. Typhimurium membrane voltage without cell lysis reduces bacterial colonization of mice.
PLoS Pathog. 2022 Jun 10;18(6):e1010606. doi: 10.1371/journal.ppat.1010606. eCollection 2022 Jun.
PLoS Pathog. 2022.
PMID: 35687608
Free PMC article.
Staphylococcal Bacterial Persister Cells, Biofilms, and Intracellular Infection Are Disrupted by JD1, a Membrane-Damaging Small Molecule.
Dombach JL, Quintana JLJ, Detweiler CS.
Dombach JL, et al.
mBio. 2021 Oct 26;12(5):e0180121. doi: 10.1128/mBio.01801-21. Epub 2021 Oct 12.
mBio. 2021.
PMID: 34634935
Free PMC article.
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A small molecule that mitigates bacterial infection disrupts Gram-negative cell membranes and is inhibited by cholesterol and neutral lipids.
Dombach JL, Quintana JLJ, Nagy TA, Wan C, Crooks AL, Yu H, Su CC, Yu EW, Shen J, Detweiler CS.
Dombach JL, et al.
PLoS Pathog. 2020 Dec 8;16(12):e1009119. doi: 10.1371/journal.ppat.1009119. eCollection 2020 Dec.
PLoS Pathog. 2020.
PMID: 33290418
Free PMC article.
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Inhibition of multiple staphylococcal growth states by a small molecule that disrupts membrane fluidity and voltage.
Dombach JL, Christensen GL, Allgood SC, Quintana JLJ, Detweiler CS.
Dombach JL, et al.
mSphere. 2024 Mar 26;9(3):e0077223. doi: 10.1128/msphere.00772-23. Epub 2024 Mar 6.
mSphere. 2024.
PMID: 38445864
Free PMC article.
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